The Fondazione GENS ONLUS, founded in 2005, favour research on the role of gene x environment interaction on the onset, progression and outcome of non-transmissible common diseases such as such as cardiovascular disorders, diabetes and cancer. Fondazione GENS ONLUS, has its roots in the WHO definition of health: " Health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity”, thus recognize a priority to contribute to improvement of public health preventive measures. Knowledge, awareness and care are the pillar to build on efficient preventive measures. Within this context we invoke a broad conception of “environment” encompassing physical and biological factors together with social, economic and cultural ones. Compelling scientific evidence shows that physical and social health and well-being are closely interwoven and deeply interdependent, and that health is influenced by a broad range of determinants that lie beyond the health sector. A better characterisation of the interactions between environmental and genetic factors is critical to understanding the pathogenesis of multifactorial diseases, which represents a major burden of morbidity and mortality for our species.